New Study shows that Pantesin® Pantethine significantly lowers bad cholesterol by 11%

March 3, 2014 New York City, NY

A recently published study in Vascular Health and Risk Management showed that Pantesin® Pantethine was effective in lowering cardiovascular risk markers in study participants with low to moderate risk factors who were eligible for statin therapy.

Specifically when compared to placebo, Pantesin showed significant changes in:

  • LDL-Cholesterol – 11% decline
  • non-HDL-Cholesterol – 7% decline
  • Total Cholesterol – 6% decline

The study also showed that Pantesin didn’t block CoQ10 which may favor the adverse effects profile as compared to statin therapy.

The research was a triple-blinded, placebo-controlled study on a North American population deemed eligible for statin therapy according to NCEP (National Cholesterol Education Program) guidelines.  Pantesin was given at a dose of 600mg/day from weeks 1-8 and 900 mg/day from weeks 9-16.  The results demonstrated significant declines in LDL-C, HDL-C and TC levels after 16 weeks with no significant measurable benefits associated with the increased dosage. It should also be noted that the positive results were over and above the benefits of following a TLC diet (Therapeutic Lifestyle Changes) that was required of both the placebo and Pantesin groups.

“This study is significant because it highlights the ability to reduce several cardiovascular risk markers with a safe and comprehensive dietary supplement,” said study co-author, Danielle Citrolo, Pharm D.

An ingredient backed by 35+ years of research validating Pantesin’s use as a dietary supplement to help maintain healthy cholesterol levels is well supported. For more about Pantesin visit or email 

Click here to view study:

Evans, M., Rumberger, J.A., Azumano, I., Napolitano, J., Citrolo. D., Kamiya, T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vascular Health and Risk Management 2014:10 89–100. 

About Pantesin
A pure and highly absorbable form of Pantethine (an active form of Vitamin B5), Pantesin provides safe and effective support for a healthy heart. Pantesin works at the cellular level, enhancing enzyme and metabolic activity to help maintain balanced cholesterol levels. For more information visit 

About Kyowa Hakko USA
Kyowa Hakko USA is the North American sales office for Kyowa Hakko Bio Co. Ltd., an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. Kyowa is the manufacturer of amino acids and related compounds as well as the branded ingredients including Cognizin® Citicoline, Pantesin® Pantethine, Setria® Glutathione, and Sustamine® L-Alanyl-L-Glutamine. For more information visit